Dementia is a major public health issue in aging population with increasing life expectancy it becomes cause of concern in the society covering a spectrum of disorders including Alzheimer’s Disease (AD), Lewy body dementia and Vascular Dementia (VD). These are multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. Early intervention to delay progression of cognitive impairments are required to improve the deficits associated with dementia. MRI imaging shows these cerebrovascular lesions as white matter hyperintensities (WMH) adding significant burden to dementia over the age. However, there is no understanding how these small infarcts by themselves do not produce any functional disability till a certain burden is reached. What are the molecular drivers for these which would lead to cognitive dysfunction? To answer these questions there is need to develop an animal model replicating transient ischemic attack seen in patients that ultimately results in irreversible dementia.