Dr. Prathima Arvind
Biosketch
Dr. Prathima Arvind completed her PhD in Human Genetics from Rajiv Gandhi University of Health Sciences (RGUHS) in 2015, where her research focused on understanding the molecular mechanisms underlying genetic diseases, particularly in the context of coronary artery disease. She used sequencing and mRNA expression data to explore these mechanisms. After completing her PhD, Dr. Arvind joined Yale University in 2017 as a postdoctoral associate in the Internal Medicine Cardiology department. During her time at Yale, she focused on blood and urine biomarker assays for heart failure and kidney disease, utilizing advanced platforms such as Meso Scale Discovery (MSD) and mass spectrometry to assess renal function and disease progression.
In 2020, Dr. Arvind joined the Centre for Brain Research (CBR) at IISc Bangalore as a Scientific Officer where she currently coordinates the TATA Longitudinal Study on Aging (TLSA) and Multimodal Intervention Study and manages the GenomeIndia project. Her responsibilities include, overseeing clinical research, coordinating large-scale population studies and genetic research, particularly in the ongoing cohort studies at CBR.
Projects
As a project coordinator for the TATA Longitudinal Study of Aging (TLSA) which includes longitudinal and intervention cohorts, Dr. Arvind manages day-to-day operations, ensuring alignment with project goals and timelines and smooth coordination among all team members. She also plays a key role in maintaining direct interactions with participants, ensuring their engagement, and addressing any concerns throughout the study.
As a project manager for the Genomeindia study, she works closely with partner centres to track the project’s progress and ensure timely updates from each centre. Dr. Arvind plays a key role in the identification and collection of population samples and is responsible for managing the receipt of samples at the CBR-Biobank, ensuring accurate tracking and documentation. Additionally, she organizes meetings and prepares detailed reports for the funding agencies to ensure that project milestones are met. She also oversees the submission of all phenotypic data to the CBR server, managing data integrity and ensuring compliance with project standards.
In her research work, she contributes to ongoing studies like candidate gene analysis within the TLSA cohort as part of the CBRIMS (CBR Intramural Support) project. Her role involves analyzing genetic variants to understand genotype and phenotype association. In addition, she contributed to the GenomeIndia dataset, focusing on the analysis of variants in long non-coding RNAs to explore their potential regulatory roles in genomic expression and disease mechanisms. This research objective has a strong translational component, aiming to bridge genomic findings with practical applications in healthcare and disease management.
Lab Members:
2. Piu Das
Work: Working on candidate gene analysis and variant analysis in long noncoding RNAs (lncRNAs) in the Indian population, aiming to identify genetic variations that may contribute to disease susceptibility and molecular mechanisms.
3. Ambalika Basak
Work: Comprehensive review on genes linked to Vascular Dementia followed by downstream analysis to identify key biological pathways and gene-gene interaction network analysis to understand the molecular mechanisms underlying the disease.
Prathima Arvind, Abhishek Mensegere, Palash Kumar Malo, Jonas Sundarakumar and Thomas Gregor Issac*. Assessment of Cognitive Status in Geriatric Individuals with a History of COVID-19 Exposure. Gerontology & Geriatric Studies. 2024, 9(1).
Jha PK, Sahu A, Prabhakar A, Tyagi T, Chatterjee T, Arvind P, Nair J, Gupta N, Kumari B, Nair V, Bajaj N, Shanker J, Sharma M, Kumar B, Ashraf MZ. Genome-Wide Expression Analysis Suggests Hypoxia-Triggered Hyper-Coagulation Leading to Venous Thrombosis at High Altitude. Thromb Haemost. 2018 Jul;118(7):1279-1295. doi: 10.1055/s-0038-1657770. Epub 2018 Jun 4. PMID: 29864786.
Arvind P, Jayashree S, Jambunathan S, Nair J, Kakkar VV. Understanding gene expression in coronary artery disease through global profiling, network analysis and independent validation of key candidate genes. J Genet. 2015 Dec;94(4):601-10. doi: 10.1007/s12041-015-0548-3. PMID: 26690514.
Arvind P, Nair J, Jambunathan S, Kakkar VV, Shanker J. CELSR2-PSRC1-SORT1 gene expression and association with coronary artery disease and plasma lipid levels in an Asian Indian cohort. J Cardiol. 2014 Nov;64(5):339-46. doi: 10.1016/j.jjcc.2014.02.012. Epub 2014 Mar 24. PMID: 24674750.
Prathima Arvind, Jayashree Shanker, Srikarthika Jambunathan and Vijay. V Kakkar. Analysis of MicroRNA Expression Profile in Asian Indians with Coronary Artery Disease. Ind. J. Sci. Res. And Tech. 2014 2(5):119-133.
Shanker J, Arvind P, Jambunathan S, Nair J, Kakkar V. Genetic analysis of the 9p21.3 CAD risk locus in Asian Indians. Thromb Haemost. 2014 May 5;111(5):960-9. doi: 10.1160/TH13-08-0706. Epub 2014 Jan 23. PMID: 24452806.
Jayashree Shanker, Prathima Arvind, Jiny Nair, Vandana Ravindran, Srikarthika Jambunathan, Vijay V Kakkar. Determining the risk of coronary artery disease using genetic markers in Asian Indians. Journal of Molecular Pathophysiology. 2014; 3(3): 38-46.
Nair J, Shanker J, Jambunathan S, Prathima Arvind, Kakkar VV, Expression Analysis of Leukotriene-Inflammatory Gene Interaction Network in Patients with Coronary Artery Disease. J. Atherosclerosis and Thrombosis. 2014 20;21(4):329-45. 2013
Shankar.J, Priyanka Setty, Prathima Arvind, Nair.J, Bhasker. D, Vijay V Kakkar Relationship
between Periodontal disease, Porphyromonas gingivalis, Peripheral vascular resistance markers and coronary artery disease in Asian Indians. Thrombosis Research, 2013 Jul; 132 (1): e8-14.
Rajani Kanth Vangala, Vandana Ravindran, Madan Ghatge, Jayashree Shanker, Prathima Arvind, Hima Bindu, Meghala Shekar, Veena S. Rao. Integrative Bioinformatics Analysis of Genomic and Proteomic Approaches to Understand the Transcriptional Regulatory Program in Coronary Artery Disease Pathways. PLoS One. 2013;8 (2): e57193
Jiny Nair, Jayashree Shanker, Prathima Arvind, Srikarthika Jambunathan, and Vijay V. Kakkar.
Association of Leukotriene Gene Variants and Plasma LTB4 Levels with Coronary Artery Disease in Asian Indians. ISRN Vascular Medicine. Volume 2013, Article ID 985743, 10 pages.
Jayashree Shanker, Arindam Maitra, Prathima Arvind, Jiny Nair, Debabrata Dash, Shibu John, Pratibha Siwach, Veena S Rao, H Sridhara, Vijay V Kakkar. Pilot Genome wide Linkage Analysis in Asian Indian Families with Coronary Artery Disease. Translational Biomedicine. 01/2012; 3(3):1-10.
Arindam Maitra, Jayashree Shanker, Debabrata Dash, Prathima Arvind, Vijay V Kakkar. Understanding the Expression of Toll like Receptors in Asian Indians Predisposed to CAD. Arch Med Sci. 2011 Oct; 7 (5): 781-7.
Jayashree Shanker, Arindam Maitra, Prathima Arvind, Jiny Nair, Debabratha Dash, Rushiraj
Manchigati, Veena Rao, Radhika, Sridhar Hebbagodi, Vijay V Kakkar. Role of Vitamin D levels and Vitamin D Receptor Polymorphisms in relation to coronary artery disease: the Indian Atherosclerosis Research Study. Coron Artery Dis. 2011 Aug; 22(5):324-32.
Diana M marlote, Tenzin Gayden, Prathima Arvind, Arvind Babu, Rene Herrera. The Soliga, an isolated tribe of southern India: genetic diversity and phylogenetic affinities. Journal of Human Genetics. 2011; 56,258-269. 2010
Arindam Maitra, Jayashree Shanker, Debabrata Dash, Prathima Arvind, Shibu John, Anupam P. Das, Pratibha Siwach, Veena S. Rao, H. Sridhara, Vijay V Polymorphisms in the pituitary growth hormone and its receptor genes associated with coronary artery disease in Asian Indians. Journal of Genetics, 2010, Vol. 89, No. 4. 2009
Maitra A, Dash D, John S, Prathima Arvind, Das AP, Shanker J, Rao VS, Sridhara H, Kakkar VV. A common variant on chromosome 9p21 associated with coronary artery disease in Asian Indians. -Journal of Genetics 2009, Apr 88 (1):113-118
Maitra A, Shanker J, Dash D, John S, Sannappa PR, Rao VS, Ramanna JK, Kakkar VV. Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease – The Indian Atherosclerosis Research Study. Thrombosis and Haemostasis 2008; 99(5):944-950.: Commention Thrombosis and Haemostasis. 2008 Jun; 99(6):991-2.
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Centre for Brain Research
Indian Institute of Science Campus
CV Raman Avenue
Bangalore 560012, India. - linkedin.com
