Prof. Thomas Gregor Issac
Biosketch
Dr. Thomas Gregor Issac completed his M.B.B.S training from M.O.S.C Medical College (Mahatma Gandhi University), Kerala from 2003-2008 and subsequently got selected for Ph.D. in Clinical Neurosciences Programme under the ICMR MD-PhD Talent Search programme which he pursued from August 2011 till July 2016. His PhD dissertation focused on the role of “Renin-Angiotensin-Aldosterone System in Cognitive deterioration in patients with cerebral small vessel disease” wherein he examined the genetic, cognitive, and neuroimaging profiles of a cohort of more than 200 patients across the spectrum of vascular cognitive impairment. Subsequently, he was selected for the MD Psychiatry course at the prestigious National Institute of Mental Health and Neurosciences (NIMHANS) and trained as a Junior Resident in the Department of Psychiatry from July 2016 to June 2019. His MD dissertation involved studying the “Role of APO E4 allele in vascular cognitive impairment”. He has also cleared DNB in Psychiatry. After his MD in psychiatry, he has completed his DM degree (Geriatric psychiatry) from NIMHANS, subsequent to which he has joined CBR as a faculty. His lab is interested in clinical research focussing on neurocognition, neuropsychiatric disorders, geriatric giants, neuro interventions, geriatric advocacy and social policy.His latest correspondence article published in Lancet Neurology ( DOI: 10.1016/S1474-4422(24)00265-5) reiterates the need for accelarating dementia research in Low and Middle Income Countries , especially India.
I have always been fascinated by clinical research and my research focuses on understanding the neurobiological underpinnings of cognitive disorders. Being from a medical background, my initial work was on the clinical understanding of the various dementias and included understanding “how, when and why” a patient with dementia shows specific clinical phenomena which often gives clues to the diagnosis and subtyping the various forms of dementia. Understanding the role of reversible causes of dementia and its mitigation is therefore of paramount importance. As the ageing population is increasing, understanding the trajectories, modifiers and modulators of healthy ageing and transition from mild cognitive impairment to major neurocognitive impairment gains significance. Targeted interventions tailored to address the vulnerable elderly from middle age or even before would be the most important translational aspect of my research. Our team also tries to understand the role of hitherto considered benign white matter changes and its role in tilting the balance of mild cognitive impairment towards dementia. My PhD work was hence specifically focused on the role of specific molecular mechanisms driving cognitive deterioration in patients with Cerebral Small Vessel Disease. This work was seminal with respect to the fact that it looked in a holistic manner not just the clinical data but comprehensively assessed the neuropsychological, imaging and genetic correlates associated with respect to the same in a cohort of more than 200 patients. This work was further extrapolated during my MD studies wherein I looked into the role of APO E4 allele in modulating the course and prognosis in the cohort of patients with vascular cognitive impairment as further ahead during my DM wherein I tried to identify the various trajectories that late-life depression would take and its likely link and evolution into neurocognitive disorders like dementia. These are just humble beginnings and there is a need for more such cohort studies in understanding the role of modifiable risk factors including epigenetics that could increase the incidence of dementia in our elderly. My research also gives importance to the public health approach for dementias and in the role of developing policy considerations, ethical and sociological aspects of ageing and explores due concerns of the stakeholders especially patients with cognitive impairment and their caregivers, rehabilitation options and inputs for advocacy as well. It is opportune that this decade is considered as that of “Healthy Ageing” by the World Health Organization (WHO) and a comprehensive understanding of geriatric physical and mental health would pave way for developing better access to pathways of care and provision of early intervention strategies and “bench to bedside” translation of research.
Ageing and Dementia in India
India’s elderly population is rapidly growing, projected to reach 340 million by 2050, bringing significant challenges in managing geriatric and neurological disorders like dementia. Government initiatives, such as the Karnataka Brain Health Initiative, helplines for the elderly, and collaborations with organizations like ARDSI and the Centre for Brain Research, aim to improve care and research for ageing populations. However, challenges persist, including inadequate infrastructure, financial constraints, and the exclusion of minority groups. Enhanced strategies, such as dementia registries, memory clinics, and age-friendly care policies, are crucial for addressing these issues effectively.
Reference: Issac TG. Ageing and dementia in India. The Lancet Neurology. 2024 Sep 1;23(9):858-9.
Hyperhomocysteinemia and its effect on ageing and language functions–HEAL study
Hyperhomocysteinemia or high levels (> 15 µmol/L) of homocysteine (Hcy)in the blood has been suggested to affect the brain through vascular and neurodegenerative pathways and potentially impact cognition.
The study recruited 1296 participants aged ≥ 45 years from Tata Longitudinal Study of Ageing (TLSA), an ongoing cohort study. The participants underwent detailed cognitive assessments using Addenbrooke’s Cognitive Examination-III (ACE-III) and Computerized Assessment of Adult Information Processing (COGNITO) neuropsychological battery and MR imaging using a 3T scanner. The participants were classified based on the median homocysteine level (16.89 µmol/L) into low Hcy (≤ median) and high Hcy (> median) groups.
When adjusted for age, gender, years of education, vitamin B12, folate and dyslipidaemia, Generalised Linear Model (GLM) found a significant association of high Hcy with vocabulary task [β (95% CI) − 1.354 (− 2.655, − 0.052); p = 0.041]. Significant associations was also obtained between cerebral white matter volume and high Hcy [β (95% CI) − 5617.182 (− 11062.762, − 173.602); p = 0.043]. The results suggest that people with high Hcy levels performed poorer in cognitive tasks related to language domain and had lesser cerebral white matter volume. This indicates that homocysteine might have a profound impact on brain structure as well as function.
Reference: Sandhya G, Monisha S, Singh S, Stezin A, Diwakar L, Issac TG. Hyperhomocysteinemia and its effect on ageing and language functions–HEAL study. Scientific Reports. 2024 Aug 29;14(1):20101.
Music and the aging brain – Exploring the role of long-term Carnatic music training on cognition and gray matter volumes
Aging is a natural process and is often associated with an increased incidence of cognitive impairment. Physical exercise, diet, and leisure activities (music, dance, and art) are some of the lifestyle factors that contribute to healthy aging.
Fifty-one healthy elderly individuals (50–80 years of age) residing in an urban locality were selected for the study from the Tata Longitudinal Study of Aging cohort. Participants were divided into two groups: Active musicians trained in Carnatic music for more than five years (n = 18) and age-matched non-musicians (n = 33). Addenbrooke cognitive examination-III, Hindi mental status examination, and trail-making test-B (TMT-B) were used to assess cognitive functioning. A Generalized Linear Regression Model was performed including covariates such as gender, age, and years of education. We also looked at the available brain magnetic resonance imaging data of a subset of our study population to inspect the volumetric differences between musicians and non-musicians.
Musicians had significantly better visuospatial abilities as compared to non-musicians (P = 0.043). Musicians (130.89 ± 45.16 s) also took less time to complete the TMT-B task than non-musicians (148.73 ± 39.65 s), although it was not a statistically significant difference (P =0.150). In addition, brain imaging data suggested that musicians had increased gray matter volumes in the right precuneus, right post-central gyrus, right medial and superior frontal gyrus, right orbital gyrus, left middle temporal gyrus, left cuneus, left fusiform gyrus, and bilateral cingulate gyrus.
(a) Three-dimensional rendered view; (b) Glass-brain view provided in SPM12; and (c) overlay of the peak cluster on the background image of regions of gray matter volume loss in non-musicians as compared to musicians in voxel-based morphometric analysis
Reference: Ghosh A, Singh S, Monisha S, Jagtap T, Issac TG. Music and the aging brain–Exploring the role of long-term Carnatic music training on cognition and gray matter volumes. Journal of Neurosciences in Rural Practice. 2024 Apr;15(2):327.
Association between multilingualism and cognitive performance among older adults in rural southern India
Recent studies have shown that multilingualism may play an important role in enhancing cognitive health. The process of language acquisition constitutes a form of natural brain training, which in turn is hypothesized to increase neuroplasticity and hence, maintains the cognitive reserve.
This study utilized cross-sectional (baseline) data from Srinivasapura Aging, Neuro Senescence and COGnition study, which is an ongoing community-based, longitudinal aging cohort study conducted in a rural setting in southern India. A total of 3725 participants were considered for the study. The participants were separated into two groups, namely, monolinguals (participants knowing one language) and multilingual (participants knowing more than one language). The cognitive performance of the participants was assessed using the Clinical Dementia Rating (CDR) Scale. In addition, bivariate analyses and binary logistic regression analyses were carried out.
The result of CDR scores with respect to language category shows that, among the monolingual participants, 86.5% were healthy individuals and 13.5% were with mild cognitive impairment (MCI). Similarly, among the multilingual, 94.3% were healthy and 5.7% were with MCI. The odds ratio value derived from logistic regression (0.69 95% CI (0.5-0.9)) that an individual has a higher chance of developing cognitive impairment if he/she is a monolingual.
Reference: Menon AJ, Malo PK, Jain S, Gandhi S, Sundarakumar JS, Rai P, Issac TG. Association between multilingualism and cognitive performance among older adults in rural southern India. Journal of Neurosciences in Rural Practice. 2024 Jan;15(1):81.
Guidelines for pharmacotherapy in Alzheimer’s disease – A primer on FDA-approved drugs
Alzheimer’s disease (AD), the most common form of dementia, is characterized by amyloid-beta (Aβ) plaques and tau protein hyperphosphorylation. FDA-approved treatments include drugs mitigating Behavioral and Psychological Symptoms of Dementia (BPSD) like brexpiprazole and suvorexant, as well as those addressing cognitive decline, such as cholinesterase inhibitors (donepezil, rivastigmine, galantamine) and glutamate regulators (memantine). Disease-modifying drugs like aducanumab and lecanemab reduce Aβ burden but carry risks like amyloid-related imaging abnormalities. Treatment selection depends on factors like patient compliance, cost, side effects, and comorbidities, alongside non-pharmacological approaches for a holistic care strategy.
Reference: Varadharajan A, Davis AD, Ghosh A, Jagtap T, Xavier A, Menon AJ, Roy D, Gandhi S, Gregor T. Guidelines for pharmacotherapy in Alzheimer’s disease–A primer on FDA-approved drugs. Journal of neurosciences in rural practice. 2023 Oct;14(4):566.
Present Members
Sandhya G
About
Ms. Dwaiti Roy
About
Ms. Aishwarya Ghosh
About
I completed my master’s degree in psychology from Banaras Hindu University. I am interested in the field of Music -Cognition, music -based interventions in neuropsychiatric disorders and in identifying music-perception-based markers of cognitive decline in aging. Currently, I am exploring the impact of Indian Classical Music on brain health. I am also a formally trained Hindustani Classical singer.
Besides research, I enjoy reading, singing, and cooking in my leisure time.
Ms. Monisha S
About
Lab Alumni
Anjana J Menon
Research Assistant
Sneha Noble
Research Assistant – FABRIC grant
Angeline Jessy S
Research Assistant – Virtual Infographics, Knowledge and workSheets (VIKAS) project
Shubham Jain
Interns
Anjali Joseph
Bangalore Medical College
Worked on Sarcopenia and cognition
Sherley D Almeida
K S Hegde Medical Academy, Nitte, (Deemed to be University) Mangalore
Worked on Centenarians in India
Tsering Lhamu
IIT Roorkee
Worked on NEUROIMAGINE project
Maryam Thomas
IISER Trivandrum
Worked on NAFLD and Cognition
Tejaswini Jagtap
Rajiv Gandhi Medical College, Thane
Worked on Music and Cognition
Ashvin Varadharajan
Armed Forces Medical College, Pune
Worked on Neurometabolomics and Neuromodulation
Anjo Xavier
NIT Rourkela
Worked on Autonomic dysfunction and Cognition
Aarjith Damian Davis
IIT Guwahati
Worked on Neuropathy and Cognition
Neha Joe
St. John’s Medical College, Bangalore
Worked on Neurometabolomics
Thomas Gregor Issac. Ageing and dementia in India. The Lancet Neurology. 2024 Sep 1;23(9):858-9. DOI: 10.1016/S1474-4422(24)00265-5
Ghosh A, Malo PK, Singh S, Monisha S, Thomas Gregor Issac. Reduced Cerebellar White Matter Volume in Musicians: A Marker of Musical Expertise. Annals of Indian Academy of Neurology. 2024 Sep 1;27(5):609-11. DOI: 10.4103/aian.aian_261_24
Sandhya G, Ghosh A, Menon AJ, Roy D, Monisha S, Thomas Gregor Issac. Hyperhomocysteinemia and its Association with Cognitive Functioning—A Cross-sectional Study from an Ageing Cohort in South India. Indian Journal of Psychological Medicine. 2024 Oct 17:02537176241285127. https://doi.org/10.1177/02537176241285127
Rai P, Sahadevan P, Thomas Gregor Issac, Sundarakumar JS. Decomposing rural-urban differences in depression prevalence: a cross-sectional analysis of two community-based southern Indian cohorts. BMJ Public Health. 2024 Dec 7;2(2). https://doi.org/10.1136/bmjph-2023-000760
Xavier A, Noble S, Joseph J, Ghosh A, Thomas Gregor Issac. Heart Rate and its Variability From Short-Term ECG Recordings as Potential Biomarkers for Detecting Mild Cognitive Impairment. American Journal of Alzheimer’s Disease & Other Dementias®. 2024 Dec 13;39:15333175241309527. https://doi.org/10.1177/15333175241309527
Varghese M, Thomas Gregor Issac, Sheeba Ninan. Cooperation [SAARC] countries. Mental Health in Older People Across Cultures. Bhugra, D., Trinh, N., Ahmed, I. (2024). Mental Health in Older People Across Cultures. United Kingdom: OUP Oxford.2024 Dec 17:92. Book Chapter on Mental Health in SAARC countries.
Malo PK, Ghosh A, Menon AJ, Sandhya G, Roy D, Thomas Gregor Issac. Effectiveness of Repetitive Transcranial Magnetic Stimulation in Mild Cognitive Impairment and Early Alzheimer’s Disease: A Systematic Review and Meta-analysis. Journal of Psychiatry Spectrum. 2025 Jan 1;4(1):91-9. DOI: 10.4103/jopsys.jopsys_31_24
Sandhya G, Monisha S, Singh S, Stezin A, Diwakar L, Thomas Gregor Issac. Hyperhomocysteinemia and its effect on ageing and language functions–HEAL study. Scientific Reports. 2024 Aug 29;14(1):20101.
Talukdar A, Anilkumar S, Maurya SK, Thomas Gregor Issac, Diwakar L. Recurrent endothelin-1 mediated vascular insult leads to cognitive impairment protected by trophic factor pleiotrophin. Experimental Neurology. 2024 Aug 26:114938.
Kalaria R, Maestre G, Mahinrad S,Alladi S, Allegri RF, Arshad F, Babalola DO, Baiyewu O, Bak TH….Thomas Gregor Issac,…et al. The 2022 symposium on dementia and brain aging in low?and middle?income countries: Highlights on research, diagnosis, care, and impact. Alzheimer’s & Dementia. 2024 May 2.
Singh S, Malo PK, Stezin A, Mensegere AL, Thomas Gregor Issac. Hippocampal subfields volume changes and its correlation with memory functions in patients with Mild Cognitive Impairment. Aging and Health Research. 2024 Mar 5:100183.https://doi.org/10.1016/j.ahr.2024.100183
Rai P, Sahadevan P, Mensegere AL, Thomas Gregor Issac, Muniz?Terrera G, Sundarakumar JS. Rural?urban disparities in the diagnosis and treatment of hypertension and diabetes among aging Indians. Alzheimer’s & Dementia. 2024 Mar 9.https://doi.org/10.1002/alz.13771
Rai P, Sundarakumar JS, Basavaraju N, Kommaddi RP, Thomas Gregor Issac. Association between ApoE ?4 genotype and attentional function in non-demented, middle-aged, and older adults from rural India. J Neurosci Rural Pract. doi: 10.25259/JNRP_272_2023
Ghosh A, Jagtap T, Thomas Gregor Issac. Cognitive Benefits of Physical Activity in the Elderly: A Narrative Review. Journal of Psychiatry Spectrum. 2024 Jan 1;3(1):4-11.
Varadharajan, Ashvin; Gandhi, Sandhya; Menon, Anjana J; Rai, Pooja; Issac, Thomas Gregor. Transcranial Alternating Current Stimulation – A Novel Way Forward in Mild Cognitive Impairment and Dementia Therapeutics. Annals of Indian Academy of Neurology ():10.4103/aian.aian_586_23, November 24, 2023. | DOI: 10.4103/aian.aian_586_23
Meghana R, Jain S, Malo PK, Stezin A, Thomas Gregor Issac. Potential modifications on verbal-language/orientation-memory ratio from Addenbrooke’s cognitive examination III to predict mild cognitive impairment from healthy controls. J Neurosci Rural Pract. 2023 Jul-Sep;14(3):531-532. doi: 10.25259/JNRP_223_2023. Epub 2023 Aug 16. PMID: 37692821; PMCID: PMC10483186.
Menon AJ, Malo PK, Jain S, Gandhi S, Sundarakumar JS, Rai P, Thomas Gregor Issac. Association between multilingualism and cognitive performance among older adults in rural southern India. J Neurosci Rural Pract, doi: 10.25259/JNRP_376_2023
Anu, K.N., Thirumoorthy, A., Antony, S. Thomas Gregor Issac, C R Vasanthra , Sivakumar PT Caregivers Journey Through Experiences of People Living with Dementia and History of Wandering Behaviour: An Indian Case Series. J. Psychosoc. Rehabil. Ment. Health (2023). https://doi.org/10.1007/s40737-023-00359-y
Singh S, Malo PK, Mensegere AL, Thomas Gregor Issac. Letter to Editor: Atrophy asymmetry in hippocampal subfields in patients with Alzheimer’s disease and mild cognitive impairment. Experimental Brain Research. 2023 Jul 28:1-1.
Menon AJ, Sandhya G, Varadharajan A, Rai P, Sundarakumar JS, Thomas Gregor Issac. Particulate Matter 2.5–Muddling the Healthy Brain. Journal of Psychiatry Spectrum. 2023 Jul 1;2(2):129-30.
Sandhya G, Thomas Gregor Issac. “Thalaikoothal”–A Less-Known Practice of Senicide in Rural India. Journal of Psychiatry Spectrum. 2023 Jul 1;2(2):127-8.
Roy D, Varadharajan A, Joe N, Jain S, Sunny AS, Thomas Gregor Issac. “Relax, Refresh, and Refocus:” A Brief Account on the Potential Utility of Snoezelen in Dementia. Journal of Psychiatry Spectrum. 2023 Jul 1;2(2):109-12.
Maestre, G., Carrillo, M., Kalaria, R., Acosta, D., Adams, L., Adoukonou, T., … & African Dementia Consortium. (2023). The Nairobi Declaration—Reducing the burden of dementia in low?and middle?income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs. Alzheimer’s & Dementia 19: 1105-1108. https://doi.org/10.1002/alz.13025
Kumar CT, Varghese M, Duddu V, Vaitheswaran S, Srivastava S, Shaji KS, …, Thomas Gregor Isaac, Chandra M. Indian Psychiatric Society multicentre study: Diagnostic patterns, comorbidity and prescription practices for patients with Dementia. Indian Journal of Psychiatry 2023;65:52-60.
Vasanthra CR, Ammapattian T, Antony S, Rao GN, Prasad KM, Anu KN, Thomas Gregor Issac and Sivakumar Palanimuthu Thangaraju. Home-based care of persons with dementia during COVID-19 pandemic: Caregivers’ experiences. Journal of Geriatric Mental Health 2022;9:9-12.
Suhas S, Malo PK, Kumar V, Thomas Gregor Issac, Chithra NK, Bhaskarapillai B, Reddy YCJ, Rao NP. Treatment strategies for serotonin reuptake inhibitor-resistant obsessive-compulsive disorder: A network meta-analysis of randomised controlled trials. The World Journal of Biological Psychiatry. 2022 Jun 14:1-16. doi: 10.1080/15622975.2022.2082525.
Sharad Philip, Thomas Gregor Issac, Arjita Sharda, Avinash Shekhar, Suicide prevention strategy in India, The Lancet Psychiatry, Volume 9, Issue 3, 2022,Page 192,ISSN 2215-0366,https://doi.org/10.1016/S2215-0366(22)00011-6.
Thomas Gregor Issac, Mukku SSR, Mangalore S, Sinha P, Sivakumar PT. Reflected image processing abnormalities in dementia – a case series and review. Neurocase. 2022 May 8:1-5. doi: 10.1080/13554794.2022.2072227. PMID: 35531907.
Issac, A.C., Thomas Gregor Issac, Baral, R., Bednall, T.C. and Thomas, T.S., 2021. Why you hide what you know: Neuroscience behind knowledge hiding. Knowledge and Process Management, 28(3), pp.266-276.
Philip S, Shoib S, Thomas Gregor Issac, Javed S. Diagnostic challenges posed by intersections between post-acute covid syndrome and neurocognitive disorders. Asian Journal of Psychiatry. 2022 Jan;67:102936. DOI: 10.1016/j.ajp.2021.102936. PMID: 34844177; PMCID: PMC8606183.
Ramesh A, Thomas Gregor Issac, Mukku SS, Sivakumar PT. Companionship and Sexual Issues in the Aging Population. Indian Journal of Psychological Medicine. 2021 Oct 5:02537176211045622.
Thomas Gregor Issac, Ramesh A, Reddy SS, Sivakumar PT, Kumar CN, Math SB. Maintenance and Welfare of Parents and Senior Citizens Act 2007: A Critical Appraisal. Indian Journal of Psychological Medicine. 2021 Oct 3:02537176211043932.
Krishna, G., Sivakumar, P.T., Dahale, A.B., Thomas Gregor Issac, Mukku, S.S.R., Unni, A.K., Sinha, P., Varghese, M. and Subramanian, S., 2020. Increased prolidase activity in Alzheimer’s dementia: A case-control study. Asian journal of psychiatry, 53, p.102242.
Thomas Gregor Issac Be in Control before You Lose Control. Journal of Neurosciences in Rural Practice, 11(3), p.365.
Mukku SS, Jagtap N, Thomas Gregor Issac, Mangalore S, Sivakumar PT. Psychotic symptoms in Frontotemporal dementia with right fronto-temporal atrophy. Asian Journal of Psychiatry. 2020 Apr 18:102040.
Krishna G, Kn A, Kumar RS, Sagar BC, Philip M, Dahale AB, Thomas Gregor Issac, Mukku SS, T Sivakumar P, Subramanian S. Higher levels of lysosomal associated membrane protein-2 (LAMP-2) in plasma exosomes from Alzheimer’s disease: An exploratory study from South India. Asian journal of psychiatry. 2019 Dec 9;48:101898.
Chandra SR, Chakravarthula NR, Thomas Gregor Issac, Philip M. Long-term follow-up of patients with multiple sclerosis treated with a cost-effective protocol from a rural medical center in India: a retrospective case series. Asia Pacific Journal of Clinical Trials: Nervous System Diseases. 2019 Oct 1;4(4):90.
Issac AC, Thomas Gregor Issac. Unravelling the Nexus between neuroscience and leadership research. Management Decision. 2019 Nov 12.
Chandra SR, Shivaram S, Thomas Gregor Issac Reflected images processing and the diseases of the brain. International Journal of Health & Allied Sciences. 2019 Jul 1;8(3):174.
Chandra SR, Koti N, Harikrishna GV, Mailankody P, Ramanujam CN, Pavagada SM, Thomas Gregor Issac. A rare treatable cause for atypical frontotemporal dementia with multiple fractures in a young female. Journal of Geriatric Mental Health. 2018 Jul 1;5(2):170.
Thomas Gregor Issac., Sivakumar, P.T., Chandra, S.R., Christopher, R., Philip, M., Rajeswaran, J. and Prasad, C., 2019, January. ROLE OF ANGIOTENSIN CONVERTING ENZYME GENE POLYMORPHISM IN COGNITIVE DETERIORATION IN PATIENTS WITH CEREBRAL SMALL VESSEL DISEASE. In INDIAN JOURNAL OF PSYCHIATRY (Vol. 61, No. 9, pp. S628-S628). WOLTERS KLUWER INDIA PVT LTD, A-202, 2ND FLR, QUBE, CTS NO 1498A-2 VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA: WOLTERS KLUWER MEDKNOW PUBLICATIONS.
Chandra SR, Suresh A, Annapoorni CSV, Rita Christopher, Asheeb A, Thomas Gregor Issa Skin, hair and nails as pointers to neurocognitive disorders in children: our experience. J Clin Psychiatry Cog Psychol. 2018;2(2):5-10.
Chandra SR, Huddar A, Varghese N, Koti N, Ganaraja VH, Pooja M and Thomas Gregor Issac. Myasthenia Gravis-Our Experience in the Last Three Years with Interesting Associations. J Gen Pract (Los Angel). 2018;6(363):2.
Thomas Gregor Issac, Telang AV, Chandra SR. Trichotillomania ranging from “ritual to illness” and as a rare clinical manifestation of frontotemporal dementia: Review of literature and case report. International journal of trichology. 2018 Mar;10(2):84.
Gowda GS, Telang A, Sharath R, Thomas Gregor Issac, Haripriya C, Ramu PS, Math SB. Use of newer technologies with existing service for family reintegration of unknown psychiatric patients: A case series. Asian Journal of Psychiatry. 2017 Oct 29.(ahead of print)-published online
Chandra SR, Thomas Gregor Issac, Gupta N. Snakebite, Antivenom and Mitochondrial Toxicity. Annals of Medical and Health Sciences Research. 2017;7(3).
Thomas Gregor Issac, Chandra SR, Gupta N, Rukmani MR, Deepika S, Sathyaprabha TN. Autonomic dysfunction: A comparative study of patients with Alzheimer’s and frontotemporal dementia – A pilot study.Journal of Neurosciences in Rural Practice. 2017;8(1):84-88.
Chandra, SR, Thomas Gregor Issac, Mane, M., Bharath, S., & Nagaraju, B. C. (2017). Long Loop Reflex 2 in Patients with Cortical Dementias: A Pilot Study.Indian Journal of Psychological Medicine 2017; 39(2), 164–168.
Chandra SR, Asheeb A, Dash, Retna N, Ravi Teja KV, Thomas Gregor Issac, Role of electroencephalography in the diagnosis and treatment of neuropsychiatric border zone syndromes. Indian J Psychological Medicine 2017;39: pages 243-249.
Chandra SR, Anand B, Thomas Gregor Issac, Median and common peroneal neuropathy in coir workers of Alappuzha district , Kerala, Annals of Indian Academy of Neurology 2017:20:23-8.
Thomas Gregor Issac, Chandra SR, “ A lady of few words” Review of literature and report of a case of Progressive Non Fluent aphasia type of frontotemporal dementia , Journal of geriatric mental health 2016;3:pages 164-167.
Chandra SR, Thomas Gregor Issac, Deepak S, Teja R, Kuruthukulangara S. Pyridoxine-dependent convulsions among children with refractory seizures: A 3-year follow-up study. J Pediatr Neurosci2016; 11:188-92.
Chandra SR, Thomas Gregor Issac, Philip. M, Gadad. V, Creutzfeldt–Jakob disease phenotype and course: Our experience from a tertiary center. Indian J Psychol Med 2016; 38:438-442.
Thomas Gregor Issac, Chandra SR. The woman who lost her words. Saudi Journal of Medical Sciences 2016; 4: 239-40.
Chandra SR, Thomas Gregor Issac, Kumar V, Pai A, Patil SA. Human cysticercosis. International Journal of Health Allied Sciences 2016; 5:174-7.
Chandra SR, Thomas Gregor Issac, Korada SK, Teja KV, PhilipM. Neuropsychiatric symptoms in a cohort of patients with frontotemporal dementia: Our experience. Indian J Psychol Med 2016; 38:326-30.
Varghese V, Chandra SR, Christopher R, Rajeswaran J, Prasad C, Subasree R, Thomas Gregor Issac. Cognitive dysfunction in patients with Neurocysticercosis. Indian J Psychol Med 2016; 38:142-146.
Thomas Gregor Issac, Chandra S.R, Rajeswaran J, Christopher R, Philip M, Demographic features and Neuropsychological correlates in a cohort of 200 patients with Vascular Cognitive Decline due to Cerebral Small Vessel disease. Indian J Psychol Med 2016; 38:127-32.
Varghese V, Chandra SR, Christopher R, Rajeswaran J, Prasad C, Subasree R, Thomas Gregor Issac. Factors determining cognitive dysfunction in cerebral small vessel disease. Indian J Psychol Med 2016; 38:56-61.
Chandra SR, Thomas Gregor Issac, Nagaraju BC, Philip M. A study of cortical excitability, central motor conduction, and cortical inhibition using single pulse transcranial magnetic stimulation in patients with early Frontotemporal and Alzheimer’s dementia. Indian J Psychol Med 2016;38:25-30.
Thomas Gregor Issac, Chandra SR, Nagaraju BC. Transcranial magnetic stimulation (TMS) as a tool for early diagnosis and prognostication in Cortico-basal ganglia degeneration (CBD) syndromes: Review of Literature and case report. Indian J Psychol Med 2016;38:81-3.
Thomas Gregor Issac, Sadandavalli Retnaswami Chandra, Rita Christopher, Jamuna Rajeswaran, and Mariamma Philip, “Cerebral Small Vessel Disease Clinical, Neuropsychological, and Radiological Phenotypes, Histopathological Correlates, and Described Genotypes: A Review,”Journal of Geriatrics, vol. 2015, Article ID 564870, 11 pages, 2015. doi:10.1155/2015/564870
Chandra SR, Thomas Gregor Issac, Shivram S. Catatonia in children following systemic illness. Indian Journal of Psychological Medicine 2015; 37:pages 413-418.
Prabhakar, P., Chandra, S. R., Supriya, M ,Thomas Gregor Issac, Prasad, C., & Christopher, R. Vitamin D status and vascular dementia due to cerebral small vessel disease in the elderly Asian Indian population.Journal of the Neurological Sciences,2015, 359:1, 108-111.
Chandra SR, Thomas Gregor Issac, Philip M, Krishnan A, Elevated anti-measles antibody titre: An association in Autoimmune encephalitis. Journal of Neurosciences in Rural Practice 2015;6:536-540.
Chandra SR, Thomas Gregor Issac, A case of mitochondrial Cytopathy with exertion induced dystonia. Journal of Pediatric Neurosciences, 2015;10:254-7.
Chandra SR, Thomas Gregor Issac, Ayyappan K. New onset psychosis as the first manifestation of neuropsychiatric lupus. A situation causing diagnostic dilemma. Indian Journal of Psychological Medicine 2015;37:pages 333-338
Chandra SR, Thomas Gregor Issac, Gayathri, N, Gupta, N,Abbas.M M, Atypical case of Myoclonic Epilepsy With Ragged Red Fibers (MERRF) and the lessons learned. Journal of Postgraduate Medicine 2015; 61pages 200-202.
Chandra SR, Thomas Gregor Issac, Gayathri N, Shivaram S. Schwartz-Jampel syndrome. Journal of Pediatric Neurosciences 2015;Issue10:pages69-71
Chandra S.R, Raj .P, Thomas Gregor Issac, Self-mutilation in Neurodegeneration with brain Iron Accumulation. Indian Journal of Dermatology 2015,Issue60,pages :290-292.
Chandra SR, Thomas Gregor Issac, Rita Christopher. Letter to Editor, Clinical features and course of Glutaric Aciduria- Report of 6 cases. Journal of Neurosciences in Rural Practice, 2015, Volume 6, Issue 2, pages 290-294.
Chandra S.R, Thomas Gregor Issac, Abbas M.M. Apraxias in Neurodegenerative dementias. Indian Journal of Psychological Medicine, 2015, Volume37, Issue 1, pages 42-47.
Thomas Gregor Issac, Soundarya .S, Christopher R, Chandra S.R, Vitamin B12 Deficiency: An Important reversible co-morbidity in Neuropsychiatric Manifestations. Indian Journal Of Psychological Medicine 2015; Volume 37, Issue1, pages 26-29.
Thomas Gregor Issac and Chandra SR, Steroid therapy: a double edged sword, Letter, Medical Science, 2014, Volume 15, Issue 61, December 2014, pages 32-33
Chandra S.R, Thomas Gregor Issac, Sindhu Krishnah, Review Article, Mobile Towers, Cell Phones and its Health consequences: Facts or Fiction, TAPI Journal Vol 6 ,Issue 3, August- December 2014, pages 1-5.
Chandra SR, Thomas Gregor Issac, Neurodegeneration and Mirror Image agnosia, Research letter, North American Journal Of Medical Sciences 2014;Volume 6:Issue 9: pages 472-477
Chandra SR, Thomas Gregor Issac. Mirror image agnosia. Indian J Psychol Med 2014 Volume: 36 Issue: 4 Page: 400-403
SR Chandra, Sahana.S, Thomas Gregor Issac; Approach to diagnosis and treatment of epilepsies; Review article; TAPI Journal Vol.6,Issue 2 ,April-July 2014 Pages 6-14..
SR Chandra, Ravi Yadav,CSPuneeth, Jitender Saini, Thomas Gregor Issac; ‘The Spectrum of Vascular Dementia’ — A Retrospective Study from South India,JAPI Issue,June 2014,vol. 62 pages 498-504.
Chandra SR, Seshadiri R, Chikabasavaiah Y, Issac TG; Progressive Limbic encephalopathy: Problems and Prospects. Annals of Indian Academy of Neurology 2014;17;166-170.
Chandra S.R, Thomas Gregor Issac; Uncommon Manifestation in a case of Mitochondrial Cytopathy; Case Report; TAPI Journal 6,Issue 4 ,January- March 2014 Pages 11-13.
Vandana V.P, Chandra S.R, Thomas Gregor Issac; Speech, Language ,Hearing and communication Disorders in Individuals with HIV/AIDS; Review Article;TAPI Journal Vol.6,Issue 4 ,January- March 2014 Pages 1-5.
SR Chandra, Thomas Gregor Issac; Battered woman Syndrome-An unusual case presentation of pseudodystonia, Case report, Journal of Neurosciences in Rural practice, April –June 2014, Vol(5), Issue 2,pages 35-37.
Sindhu Krishnah CS, Chandra SR, Thomas Gregor Issac, Sanjith, Radhamma H; Legal and Ethical aspects in Nursing Practice- Review article; TAPI Journal ,Vol 5, issue 3,Pages 12-15 September- December 2013.
Vandana V.P, Chandra S.R, Thomas Gregor Issac; Influence of AAC modes on Speech Intelligibility in a speaker with spastic-flaccid Dysarthria due to Amyotrophic lateral Sclerosis; TAPI Journal ,Vol 5, issue 3,Pages 1-5 September- December 2013.
Thomas Gregor Issac, ChandraR, Nagaraju B.C; Transcranial Magnetic Stimulation in patients with early cortical dementias: A Pilot Study. Annals of Indian Academy of Neurology 2013; 16;619-622.
Clinical and Radiological Spectrum of CSF Anti-Measles Antibody associated Encephalopathy- Chandra SR, Thomas Gregor Issac, Ramakrishna A; TAPI journal Vol 5, Issue 2 ,May-august 2013; pgs1-6.
Munivenkatappa A, Devi B.I, Thomas Gregor Issac, Bhat D.I, Kumaraswamy A.D, Shukla D.P; Bicycle Accident –related head injuries in India: Journal of Neurosciences in Rural practice 2013,Vol 4 pages 262-266
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